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Losartan selectively blocks the AT 1 receptorIn vitro and in vivo losartan and its pharmacologically active carboxylic acid metabolite E-3174 block all physiologically relevant actions of angiotensin IIregardless of the source or route of its synthesis.
Losartan is not recommended in children with hepatic impairmentsee section 4.2
Other antihypertensive agents may increase the hypotensive action of losartanConcomitant use with other substances which may induce hypotension as an adverse reactionlike tricyclic antidepressantsantipsychoticsbaclofen and amifostinemay increase the risk of hypotension.
Do not use Cozaar if you are pregnantIf you become pregnantstop taking this medicine and tell your doctor right awayLosartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
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